UA Health Sciences

Services

The goal of the Biorepository is to facilitate biomedical research at the University of Arizona using cells and tissues obtained from patients and other clinical sources.   The following services are offered to support this goal.

Services Offered Directly by the Biorepository

Processing and banking of viable cells/specimens/tissues: Investigator-provided cell and tissue samples are processed and viably cryopreserved for later use in research or clinical studies.  Biorepository or investigator-provided SOPs are utilized for these purposes.

Specimen phenotyping: Both protein and molecular phenotyping of cells and tissues is available including flow cytometric characterization, histo- and immunohistochemistry, as well as genomic arrays.

Viable cell population isolation and banking: Isolation of subpopulations of interest from cellular and tissue specimens is available including phenotypic characterization and long-term banking.

DNA/RNA/Protein isolation and banking: Investigators may request specimens be processed to obtain DNA, RNA and/or proteins for immediate analyses as well as for long-term banking.

Assistance with Regulatory issues: Assistance will be provided for those investigators needing their samples processed and banked under cGTP conditions such that the specimens can be use clinically at a later time.  In addition, assistance can be provided with IRB and IND applications.

Banking of frozen tissue specimens: Investigator is provided banked frozen tissue specimen, along with Pathologist-reviewed H&E-stained frozen section for quality assurance, and basic clinicopathological information distilled from the Pathology report.

Fresh tissue specimens: Investigator is provided freshly procured tissue specimens, typically for studies requiring viable cells, and basic clinicopathological information distilled from the Pathology report.

Banked frozen serum/plasma specimens: Investigator is provided banked frozen serum or plasma specimens, and basic clinic pathological information distilled from the Pathology report.

Banked leukocyte DNA: Investigator is provided banked leuckocyte DNA, and basic clinicopathological information distilled from the Pathology report.

Serum/plasma procurement: Investigator is provided serum or plasma procured and processed by the Biorepository, and linked to the investigator's project-specific consent.

Services Offered Through the Department of Pathology:

Formalin-fixed paraffin-embedded tissue: Investigator is provided with paraffin-embedded tissues (typically as thick sections), either from the Pathology Department archive or the separate Tissue Bank research archive, along with Pathologist-reviewed H&E-stained paraffin section for quality assurance, and basic clinicopathological information distilled from the Pathology report.

Tissue procurement: Investigator is provided tissue procured by the Biorepository, and linked to the investigator's project-specific consent.

H&E-stained frozen section: Investigator is provided an H&E-stained slide of sectioned frozen tissue specimen. No extra charge if provided with tissue specimen.

Unstained frozen section: Investigator is provided an unstained slide of sectioned frozen tissue specimen. Additional unstained slides from the same specimen are available at a reduced price.

H&E-stained paraffin section: Investigator is provided an H&E-stained slide of sectioned paraffin tissue specimen. No extra charge if provided with tissue specimen.

Unstained paraffin section: Investigator is provided an unstained slide of sectioned paraffin tissue specimen. Additional unstained slides from the same specimen are available at a reduced price.

Pathology report: Investigator is provided basic clinicopathological information distilled from the Pathology report. No extra charge if provided with tissue specimen.

Review of slides: A pathologist performs review of H&E-stained slide(s) from a surgical case. No extra charge if provided with tissue specimen